Impaired Interneuron Development afterFoxg1Disruption

Transcriptional regulation of cortical interneuron development.

Simon J. B. Butt,1 Inma Cobos,2 Jeffrey Golden,3 Nicoletta Kessaris,4 Vassilis Pachnis,5 and Stewart Anderson6 1Skirball Institute, New York University, New York, New York 10016, 2Department of Cell Biology, University of Barcelona, 08007 Barcelona, Spain, 3Department of Pathology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, 4Wolfson Institute for Biomedical Research,...

Dlx Gene Regulation of Zebrafish GABAergic Interneuron Development

The Cell-Intrinsic Requirement of Sox6 for Cortical Interneuron Development

We describe the role of Sox6 in cortical interneuron development, from a cellular to a behavioral level. We identify Sox6 as a protein expressed continuously within MGE-derived cortical interneurons from postmitotic progenitor stages into adulthood. Both its expression pattern and null phenotype suggests that Sox6 gene function is closely linked to that of Lhx6. In both Lhx6 and Sox6 null anima...

12-P014 Interneuron development in the Zebrafish spinal cord

During development of the central nervous system, neurons pass through windows of vulnerability to environmental factors. Two windows are gestational day (G) 7 (during gastrulation) and G12 (early neuronal generation). The present study examined the effects of ethanol exposure at these times on social behavior and on the number of neurons in the central nucleus of the amygdala (Ce), which is im...

Glycine receptors regulate interneuron differentiation during spinal network development.

Glycinergic and GABAergic excitatory chloride-mediated signaling is often the first form of activity to emerge in the nascent nervous system and has been proposed to be essential for several aspects of nervous system development. However, few studies have examined the effects of disrupting glycinergic transmission. Here we perturbed glycinergic transmission in vivo from the onset of development...